E-poster Presentation 2014 World Cancer Congress

Correlations between perfusion and intravoxel incoherent motion (IVIM) diffusion in nasopharyngeal carcinoma (#750)

xiaoping yu 1 , qiang Lu 1 , feiping Li 1
  1. Hunan Cancer Tumor, Yuelu District, Changsha, HUNAN, China

Background: The relationship between the two new functional magnetic resonance techniques (dynamic contrast-enhanced T1-weighted MR perfusion [DCE-MRI] and  intravoxel incoherent motion diffusion MR[IVIM-MRI] ) for nasopharyngeal carcinoma (NPC)  has not been well understood

Aim:To study the correlations between  DCE-MRI parameters and IVIM-MRI parameters in NPC

Methods:30 patients with NPC underwent DCE-MRI and multi-b value based  IVIM-MRI (b=0, 50, 80, 100,150,200,400,600,800, 1000s/mm2) on a 1.5T MR scanner. For each primary tumor, DCE-MRI parameters including Ktrans (volume transfer constant), Ve (volume fraction) , fPV (fractional plasma volume) and kep as well as IVIM-MRI parameters (apparent diffusion coefficient [ADC], D [pure diffusion coefficient] , D* [pseudo-diffusion coefficient] and f[fraction of D*] ) were obtained respectively from the DCE-MRI and IVIM-MRI data. Pearson correlation coefficients between DCE-MRI parameters and IVIM-MRI parameters were calculated

Results: The Ktrans ,Kep ,Ve and fPV values of NPC were 0.336±0.094/min, 1.502±0.420/min, 0.234±0.053 and 0.008 ±0.009 respectively; whereas the ADC, D, D*, f of the corresponding NPC were (0.950±0.175) × 10-3 mm2 /s, (0.685 ±0.113)× 10-3 mm2 /s,(0.020 ± 0.018 ) × 10-3 mm2 /s and (0.315 ±0.102) × 10-3 mm2 /s respectively. Ve value revealed a significant correlation with D* values(r=0.450, p=0.013). Ktrans value showed correlation with D* values(r=0.378, p=0.039). However Kep and fPV values did not show significant statistical correlation with the IVIM-MRI parameters (shown in the following table)

DCE-MRI

ADC

D

D*

f

parameters

r

p

R

p

r

p

r

p

Ktrans

0.246

0.190

0.180

0.342

0.378

0.039

-0.288

0.123

Kep

0.126

0.506

0.084

0.661

0.005

0.981

-0.227

0.228

Ve

0.069

0.716

0.102

0.590

0.450

0.013

-0.019

0.921

fPV

0.021

0.911

-0.083

0.665

-0.115

0.546

0.011

0.956


Conclusions:Ktrans and fPV values of the DCE-MRI showed significant correlation with the IVIM-MRI parameters. The underlying physiological mechanism is to be studied