E-poster Presentation 2014 World Cancer Congress

Correlation Between Parameters of Dynamic-Contrast Enhanced MRI and Clinical Stage of Nasopharyngeal Carcinoma (#948)

xiaoping yu 1 , qiang Lu 1 , feiping Li 1
  1. Hunan Cancer Tumor, Yuelu District, Changsha, HUNAN, China

Background:The value of Dynamic Contrast-Enhanced MRI(DCE-MRI)in Nasopharyngeal Carcinoma(NPC)has not been well understood so far

Aim:to evaluate the role of DCE-MRI parameters in assessing clinical characteristic of NPC

Methods:Quantitative parameters (Ktrans [volume transfer constant], Ve [volume fraction] , fPV [fractional plasma volume] and kep[kep=Ktrans/Ve]) and semiquantitative parameters (TTP[time to peak],CER[contrast enhancement ratio], Maxslop[the maximum slope of the time-SI curve],WoutSl[Washout ratio of the time-SI curve],Area under the time-SI curve from initial time point of enhancement to 90sec[AUC90]and 180sec[AUC180])were obtained from the DCE-MRI data of the primary lesions of 75 NPC patients who successfully underwent DCE-MRI on a 1.5T MR scanner. Pearson correlation coefficients between DCE-MRI parameters and clinical stage(TNM and UICC staging) were calculated.

Results:Ktrans ,Ve, AUC90 and AUC180 showed positive correlation with UICC stage, T stage and M stage. Kep showed negative correlation with T stage. TTP showed positive correlation with UICC stage and T stage(shown in the following table).

DCE-MRI

UICC

stage

T

stage

N

stage

M

stage

parameters

r

p

r

p

r

p

r

p

Ktrans

0.240

0.038

0.257

0.026

-0.002

0.990

0.438

0.000

Kep

-0.191

0.101

-0.288

0.012

-0.108

0.355

0.125

0.285

Ve

0.418

0.000

0.466

0.000

0.123

0.293

0.269

0.020

fPV

0.024

0.836

-0.082

0.482

0.118

0.315

0.061

0.605

TTP

0.231

0.046

0.318

0.005

0.136

0.244

-0.062

0.598

Maxslop

0.040

0.736

0.048

0.680

-0.063

0.591

0.173

0.139

CER

0.079

0.502

-0.008

0.947

0.027

0.819

0.121

0.299

WoutSl

0.017

0.886

-0.075

0.525

-0.065

0.579

0.125

0.286

AUC90

0.362

0.001

0.380

0.001

0.100

0.391

0.446

0.000

AUC180

0.380

0.001

0.405

0.000

0.123

0.295

0.423

0.000


Conclusions:Being useful for characterising the neovasculature and permeability of primary NPC lesion, Some quantitative and semiquantitative parameters of DCE-MRI show correlation with clinical stage of NPC. These DCE-MRI parameters  might be the potential noninvasive radiological prognostic indicators of NPC



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