E-poster Presentation 2014 World Cancer Congress

Background: The relationship between the two new functional magnetic resonance techniques (dynamic contrast-enhanced T1-weighted MR perfusion [DCE-MRI] and  intravoxel incoherent motion diffusion MR[IVIM-MRI] ) for nasopharyngeal carcinoma (NPC)  has not been well understood

Aim:To study the correlations between  DCE-MRI parameters and IVIM-MRI parameters in NPC

Methods:30 patients with NPC underwent DCE-MRI and multi-b value based  IVIM-MRI (b=0, 50, 80, 100,150,200,400,600,800, 1000s/mm²) on a 1.5T MR scanner. For each primary tumor, DCE-MRI parameters including Ktrans (volume transfer constant), Ve (volume fraction) , fPV (fractional plasma volume) and kep as well as IVIM-MRI parameters (apparent diffusion coefficient [ADC], D [pure diffusion coefficient] , D* [pseudo-diffusion coefficient] and f[fraction of D*] ) were obtained respectively from the DCE-MRI and IVIM-MRI data. Pearson correlation coefficients between DCE-MRI parameters and IVIM-MRI parameters were calculated

Results: The Ktrans ,Kep ,Ve and fPV values of NPC were 0.336±0.094/min, 1.502±0.420/min, 0.234±0.053 and 0.008 ±0.009 respectively; whereas the ADC, D, D*, f of the corresponding NPC were (0.950±0.175) × 10^-3 mm² /s, (0.685 ±0.113)× 10^-3 mm² /s,(0.020 ± 0.018 ) × 10^-3 mm² /s and (0.315 ±0.102) × 10^-3 mm² /s respectively. Ve value revealed a significant correlation with D* values(r=0.450, p=0.013). Ktrans value showed correlation with D* values(r=0.378, p=0.039). However Kep and fPV values did not show significant statistical correlation with the IVIM-MRI parameters (shown in the following table)

Conclusions:Ktrans and fPV values of the DCE-MRI showed significant correlation with the IVIM-MRI parameters. The underlying physiological mechanism is to be studied