Rapid Fire Session 2014 World Cancer Congress

Exercise training and Inflammatory blood biomarkers in Breast cancer patients: a metaanalysis of randomized-controlled trials  (#370)

Jose F Meneses-Echavez 1 , Robinson Ramírez-Vélez 1 , Emilio González-Jiménez 2 , María José Sánchez Pérez 3 , Esther Molina Montes 3 , Jacqueline Schmidt Río-Valle 2
  1. Facultad de Cultura Física, Deporte y Recreación, Universidad Santo Tomás, Bogotá, DC, Colombia
  2. Facultad de Enfermería, Universidad de Granada, Granada, España
  3. Instituto de Investigación Biosanitaria de Granada (Granada.ibs), Escuela Andaluza de Salud Pública, Granada, España


It has been widely known that inflammatory biomarkers play a crucial role in tumorigenesis, angiogenesis and metastasis. Exercise training has been proposed as a safe and effective non-pharmacological strategy in modulating inflammatory status among breast cancer patients; however this evidence remains unclear. 


To determine the effects of exercise training in the blood parameters of Inflammatory biomarkers in Breast cancer patients through a metaanalysis of randomized-controlled trials. 


PRISMA statement and the Cochrane Handbook were followed. Electronic searches were implemented in MEDLINE, CENTRAL, EMBASE, Scopus and DARE database to retrieve trials published between 1980- March 2014 providing effects of exercise interventions on pro-inflammatory biomarkers, such as  interleukin (IL) -2, IL-6, IL-8, tumoral necrosis factor alpha (TNF-α) and C-reactive protein (CRP) in Breast cancer survivors. We conducted an Inverse of variance (IV) fixed-effects model in absence of heterogeneity (I2<50%); otherwise a random-effects model was selected. Standardized-Mean Differences (SMD) were calculated to estimate differences between groups (p<0.05 with 95% Confidence interval). Heterogeneity was measured with the Chi2 test (p<0.10) and I2statistics.


 A total of 15 studies were included (n=1447; mean age= 51.6 years old). Exercise interventions resulted in positive effects for CRP (MD= 0.37, 95%CI, 0.04 to 0.71; p= 0.03; I2=15%), IL-2 (MD= -6.04, 85%CI, -11.41 to -0.67; p=0.03; I2=0%), IL-10 (-22.90, 95%CI, -41.27 to -4.53; p=0.001, I2=0%) and waist circumference as indicator of body composition (MD= -1.12, 95%CI, -2.06 to -0.18; p=0.02; I2=45%). Non-significant differences were observed for IL-6 and TNF- α. There was no evidence of publication bias.


These findings suggest that exercise improves the pro-inflammatory profile in breast cancer patients and consequently the immunological responses and the carcinogenic processes related to tumoral environment. Differences found for IL-10 provide novel  evidence for the role of exercise as an effective anti-inflammatory intervention in Breast cancer patients.