Background:Variations in serum androgen and estradiol levels in men with prostate disease in Calabar Metropolis was studied.
To asses the relationship between PSA and the hormones measured and the relationship of the hormones with themselves
133 patients with prostate cancer (PC), 74 with Benign Prostatic Hyperplasia (BPH) and 60 apparently healthy men were selected for the study. Patients were further divided into prostate cancer group (133) and BPH (74). Those with prostate cancer were divided into fresh cases, and those on various forms of treatment. Serum Testosterone, Dihydrotestosterone, Dehydroepiandosterone, Estradiol, and Prostate Specific Antigen was determined using standard methods.
Serum PSA was significantly higher (p<5.00) in men with PC and BPH. Treated cases of cancer had relatively lower values than fresh cancer (FC) cases but significantly higher values than controls (p<0.05).E2/DHT was significantly higher (p<0.05) in prostate cancer than in controls. FC had significantly higher (p<0.05) serum E2/DHT than Hormone Manipulation (HM), significantly higher E2, E2/DHT and E2/T ratio than men on Orchiectomy and Hormone Manipulation (OHM). HM showed significantly higher (p<0.05) serum levels of E2, E2/DHT and E2/T than OHM. BPH had significantly higher (p<0.05) E2/T than controls. Dihydrotestosterone and Testosterone and Estradiol and Testosterone showed a strong association (r=0.268; p=0.000, r=0.295; p<0.011) in FC and (r=0.252; p=0.033, r=0.420; p=0.000) in the BPH group. In the controls, Estradiol and Testosterone showed a strong association (r=0.338; p=0.008).
The lower levels of E2 seen in men who had undergone orchiectomy and are on hormone manipulation than in other groups tends to give the best expectation in terms of management of prostate cancer patients and these patients have the best survival rates than those on hormone manipulation alone.