E-poster Presentation 2014 World Cancer Congress

The correlation between history of breastfeeding and the incidence  of childhood acute leukemia in Semarang, Indonesia (#834)

Yetty Nency 1 , Rizky Fardhani 1 , Samuel Wibawa 1 , Helmia Farida 1 , Ferdy Cayami 1
  1. Faculty of Medicine, Diponegoro Univ/ Kariadi Hospital, Semarang JawaTengah, Indonesia


Acute leukemia is  the most frequent childhood cancer. Breast milk as the best nutrition for baby known has  antimicrobial, anti-inflammatory and immune modulatory components for preventing the occurrence of childhood infection and malignancies a well.


To analyze the correlation  between the history of breastfeeding and the incidence  of acute childhood leukemia (Acute Lymphoblastic  Leukemia (ALL) and Acute Myelocytic Lekemia(AML)  in Semarang Indonesia.


A case control study involving acute leukemia patients aged 1-14 year-old at Kariadi Hospital Semarang in 2013 until April 2014. The control group was age and gender matched healthy children. The parents were interviewed  about breastfeeding history including duration, tipe of breastfeeding and exclusive  breastfeed. Data about familial malignancy, maternal radiation, infection and alcoholism were collected using a questionnaire. Exclusive breastfeeding defined as the baby  had breastmilk only until 4-6 month. Statistical analysis  used were logistic regression and  Mann Whitney


In total107 patients involved whereas ALL 85 patients (79.4%), AML  21 patients (19.6%) and mixed leukemia 1 (0.9%).  Exclusive breastfeeding  was more frequently found in healthy children  than in lekemic (74.76% vs 53.27%), OR  0.385, 95% CI(0.21-0.68)p 0.001.  The median of breasfeeding duration was longer in healthy children 12.27 month (IQR 3-24) than lekemic 1.5(IQR 1-8) p=<0.01 . By used regression analysis showed OR and  95%CI  for familial malignancy1.95(0.4-2.06)p0.16,  infection 0.58(0.11-6.36)p0.88 and alcoholism 0.0 (0.0)p0.99 respectively.


Exclusive breastfeeding is protective factor for acute leukemia. Acute leukemia patients had breasfeeding shorter than healthy children. Familial malignancy,maternal radiation,infection and alcoholism were not  the risk  factors for  acute leukemia.