Rapid Fire Session 2014 World Cancer Congress

A high LDL-C to HDL-C ratio predicts poor prognosis for initially metastatic colorectal cancer patients with elevations in LDL-C (#443)

Wen-zhuo He 1 , Liang-ping Xia 2 , Bei Zhang 3
  1. Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, guangzhou
  2. Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, guangzhou
  3. Sun yat-sen university, Guangzhou, China

Background:Though lipid disequilibrium has been documented for several types of cancer including colorectal cancer (CRC), it remains unknown whether lipid parameters are associated with the outcome of metastatic CRC (mCRC) patients.

Aim:We retrospectively examined the lipid profiles of 453 mCRC patients and investigated whether any of the lipid parameters correlated with the outcome of mCRC patients.

Methods:Pretreatment serum lipids, including triglyceride, cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), were collected in 453 initially mCRC patients. The LDL-C to HDL-C ratio (LHR) was calculated and divided into the first, second and third tertile. Univariate and multivariate analyses were performed to evaluate the impact of lipids on overall survival (OS) and progression free survival (PFS).

Results:Nearly two fifths of the patients (41.3%) exhibited elevations in LDL-C while most patients (88.3%) showed normal HDL-C levels Decreased HDL-C (P=0.035) and increased LDL-C (P=0.023) were prognostic factors for poor OS, while triglyceride (P=0.542) and cholesterol (P=0.215) were not. Multivariate analysis revealed that LDL-C (P=0.031) was an independent prognostic factor. Triglyceride, cholesterol, HDL-C and LDL-C did not correlate with PFS. Among patients with elevations in LDL-C levels, patients in the third tertile of the LHR had a markedly shorter mean OS compared to those in the 1st or 2nd tertile (P=0.012).

Conclusions:Increased LDL-C level is an independent prognostic factor for poor prognosis in mCRC patients and a high LHR predicts poor prognosis for initially mCRC patients with elevations in LDL-C.

  1. Rose G, Blackburn H, Keys A, Taylor HL, Kannel WB, Paul O, Reid DD, Stamler J: Colon cancer and blood-cholesterol. Lancet 1974, 1:181-183.
  2. Liu YL, Qian HX, Qin L, Zhou XJ, Zhang B: Serum LDL-C and LDL-C/HDL-C ratio are positively correlated to lymph node stages in males with colorectal cancer. Hepatogastroenterology 2011, 58:383-387.
  3. Serum lipid profile in colorectal cancer patients with and without synchronous distant metastases. Oncology 2005, 68:371-374.
  4. Muntoni S, Atzori L, Mereu R, Satta G, Macis MD, Congia M, Tedde A, Desogus A: Serum lipoproteins and cancer. Nutr Metab Cardiovasc Dis 2009, 19:218-225.