Abstract oral session 2014 World Cancer Congress

Green Tea Consumption Is Associated with a Reduced Risk of Adult Leukemia (#332)

Ping Liu 1 , C D’Arcy J Holman 1 , Jie Jin 2 , Min Zhang 3
  1. School of Population Health, The University of Western Australia, Perth, WA, Australia
  2. Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, Zhejiang, China
  3. Curtin Monash Accident Research Center, Faculty of Health Sciences, Curtin University, Perth, WA, Australia


Tea polyphenols have consistently demonstrated leukemic-inhibition in numerous vivo and vitro studies [1-6].  However, epidemiologic studies on the association between tea consumption and adult leukemia risk are limited and inconclusive [7-12].


A case-control study conducted in China between 2008 and 2012 to investigate the association between tea consumption and adult leukemia risk.


This included 493 incident, hematologically confirmed leukemia cases and 493 outpatient controls matched to each case by gender, year-of-birth quinquennium, and study site.  Information on type, duration, frequency, and quantity of tea consumption, diet, lifestyle, and demographic characteristics was collected by face-to-face interview using a reliable structured questionnaire.  Odds ratios (ORs) were estimated using conditional logistic regression after adjusted for resident locality, education, tobacco smoking, alcohol consumption, and fruits intake.


Among cases with leukemia subtype information (414 out of 493), 67.6% were acute myeloid leukemia, 16.9% acute lymphoblastic leukemia, 10.4% chronic myeloid leukemia, and 5.1% chronic lymphocytic leukemia.  There were 49.5% of the cases who drank tea compared with 65.9% of the controls.  Among tea drinkers, 95.8% reported drinking green tea only or green tea with black or oolong tea.  Compared with non-tea drinkers, the adjusted ORs (95% confidence intervals) were 0.30 (0.17-0.54), 0.26 (0.16-0.42), and 0.28 (0.17-0.47) for those who consumed tea ≥30 years, ≥2 cups daily, and dried tealeaves >1000g annually, respectively.  A significant inverse relationship was observed across all tea measurements with a statistically significant test for trend (P <0.001).  In analysis of leukaemia subtype, higher tea consumption was associated with a lower risk of acute myeloid leukaemia.  The inverse association existed in both males and females after stratification, and a greater risk reduction was observed in females.


We conclude that regular daily consumption of green tea can protect against adult leukemia.

  1. Britschgi A, Simon HU, Tobler A, Fey MF, Tschan MP. Epigallocatechin-3-gallate induces cell death in acute myeloid leukaemia cells and supports all-trans retinoic acid-induced neutrophil differentiation via death-associated protein kinase 2. Br J Haematol 2010;149:55–64.
  2. Ly BT, Chi HT, Yamagishi M, Kano Y, Hara Y, Nakano K, et al. Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells. PloS One 2013;8:e66378.
  3. Nakagawa H, Hasumi K, Woo JT, Nagai K, Wachi M. Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate. Carcinogenesis 2004;25:1567–74.
  4. Sonoda J, Koriyama C, Yamamoto S, Kozako T, Li HC, Lema C, et al. HTLV-1 provirus load in peripheral blood lymphocytes of HTLV-1 carriers is diminished by green tea drinking. Cancer Sci 2004;95:596–601.
  5. Lee YK, Bone ND, Strege AK, Shanafelt TD, Jelinek DF, Kay NE. VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia. Blood 2004;104:788–94.
  6. Iwasaki R, Ito K, Ishida T, Hamanoue M, Adachi S, Watanabe T, et al. Catechin, green tea component, causes caspase-independent necrosis-like cell death in chronic myelogenous leukemia. Cancer Sci 2009;100:349–56.
  7. Li Y, Moysich KB, Baer MR, Weiss JR, Brasure J, Graham S, et al. Intakes of selected food groups and beverages and adult acute myeloid leukemia. Leuk Res 2006;30:1507–15.
  8. Ma X, Park Y, Mayne ST, Wang R, Sinha R, Hollenbeck AR, et al. Diet, lifestyle, and acute myeloid leukemia in the NIH-AARP cohort. Am J Epidemiol 2010;171:312–22.
  9. Kabat GC, Wu JW, Moore SC, Morton LM, Park Y, Hollenbeck AR, et al. Lifestyle and dietary factors in relation to risk of chronic myeloid leukemia in the NIH-AARP Diet and Health Study. Cancer Epidemiol Biomarkers Prev 2013;22:848–54.
  10. Zhang M, Zhao X, Zhang X, Holman CD. Possible protective effect of green tea intake on risk of adult leukaemia. Br J Cancer 2008;98:168–70.
  11. Kuo YC, Yu CL, Liu CY, Wang SF, Pan PC, Wu MT, et al. A population-based, case-control study of green tea consumption and leukemia risk in southwestern Taiwan. Cancer Causes Control 2009;20:57–65.
  12. Naganuma T, Kuriyama S, Kakizaki M, Sone T, Nakaya N, Ohmori-Matsuda K, et al. Green tea consumption and hematologic malignancies in Japan: the Ohsaki study. Am J Epidemiol 2009;170:730–8.